Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943
AbstractPurpose[11C]P943 is a novel, highly selective 5-HT1B PET radioligand. The aim of this study was to determine the test–retest reliability of [11C]P943 using two different modeling methods and to...
View ArticleSynaptic plasticity and depression: new insights from stress and rapid-acting...
Ron Duman and colleagues discuss recent insights into a role for circuit disruption in the mechanisms of stress-induced depression. Furthermore they discuss the potential for rapid-acting...
View ArticleUndergraduate Neuroscience Majors: A Missed Opportunity for Psychiatry...
AbstractObjectiveThis study sought to determine whether and to what extent medical students with an undergraduate college major in neuroscience, relative to other college majors, pursue psychiatry...
View ArticleSynaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a...
AbstractPurpose of ReviewStudies of the neurobiology and treatment of PTSD have highlighted many aspects of the pathophysiology of this disorder that might be relevant to treatment. The purpose of this...
View ArticleKetamine: A Promising Rapid-Acting Antidepressant
AbstractThe monoaminergic deficiency hypothesis of depression has dominated the field of mood disorders research for several decades. This hypothesis has led to many advancements, including the...
View ArticleMinimal Clinically Important Differences (MCID) in Assessing Outcomes of...
AbstractThis study sought to determine the minimal clinically important difference (MCID) for two frequently used measures of symptom severity in Post-Traumatic Stress Disorder: the Clinician...
View ArticleMachine learning selected smoking-associated DNA methylation signatures that...
AbstractBackgroundThe effects of tobacco smoking on epigenome-wide methylation signatures in white blood cells (WBCs) collected from persons living with HIV may have important implications for their...
View ArticleEnhancing the Utility of Preclinical Research in Neuropsychiatry Drug...
AbstractMost large pharmaceutical companies have downscaled or closed their clinical neuroscience research programs in response to the low clinical success rate for drugs that showed tremendous promise...
View ArticleNeural computations of threat in the aftermath of combat trauma
AbstractBy combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in...
View ArticleAuthor Correction: Neural computations of threat in the aftermath of combat...
The original and corrected figures are shown in the accompanying Author Correction.
View ArticleImaging the glutamate synapse
A new positron emission tomography radiotracer enables imaging of the human glutamate receptor AMPA-R, a fundamental component of neurotransmission involved in neuropsychiatric disorders.
View ArticleResponding to the hidden pandemic for healthcare workers: stress
Healthcare workers are having to work under incredibly stressful conditions. Videoconferencing can be harnessed to provide mental-health support, but some report ‘tele-health’ fatigue. To protect...
View ArticlePublisher Correction: Responding to the hidden pandemic for healthcare...
A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01176-7
View ArticleTranscriptomic organization of the human brain in post-traumatic stress disorder
AbstractDespite extensive study of the neurobiological correlates of post-traumatic stress disorder (PTSD), little is known about its molecular determinants. Here, differential gene expression and...
View ArticleMultivariate genome-wide analysis of education, socioeconomic status and...
AbstractSocioeconomic status (SES) and education (EDU) are phenotypically associated with psychiatric disorders and behaviours. It remains unclear how these associations influence genetic risk for...
View ArticleFunctional brain networks reflect spatial and temporal autocorrelation
AbstractHigh-throughput experimental methods in neuroscience have led to an explosion of techniques for measuring complex interactions and multi-dimensional patterns. However, whether sophisticated...
View ArticleA computational model for learning from repeated traumatic experiences under...
AbstractTraumatic events can lead to lifelong, inflexible adaptations in threat perception and behavior, which characterize posttraumatic stress disorder (PTSD). This process involves associations...
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